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火狐体育官方网站zuoyiluojiashan,huanraodonghushui,lvshuchengyin,huaxiangliuyi。xuebuyuanyu1943nianchenglidehubeishengshengliyixueyuan,xianzaishi火狐体育liudaxuebuzhiyi。 xuebuhanjichuyixueyuan、diyilinchuangxueyuan、dierlinchuangxueyuan、kouqiangyixueyuan、yaoxueyuan、jiankangxueyuan、zhiyejishuxueyuan...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759364
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵章晓联李红良卿国良
百千万人才工程选者: 舒红兵、黄从新章晓联 
万人计划: 领军人才:舒红兵唐其柱李红良      
教育部新世纪优秀人才: 章晓联、何小华乐江、 于红刚 李雁郑芳、
胡锦跃、 黄鹤、李红良、 张 旗、 叶晓茜、 尚政军、 郭继华、 张玉峰、
周海兵、 刘天罡、 王连荣、 瞿旭东、洪 葵

姓名:邓子新

单位:火狐体育药学院

职称:院士、院长

邮箱:zxdeng@frndzcloud.com

联系电话:

研究方向:

1.微生物药物的合成途径、代谢工程及合成生物学,DNA硫修饰的遗传、生理及生化研究









代表性论著:

1. Xu T, Yao F, Zhou X, Deng Z, You D (2010). A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella. Nucleic Acids Research. Jul 12. [Epub ahead of print].

2. shao y, he x, harrison em, tai c, ou hy, rajakumar k, deng z (2010). mgenomesubtractor: a web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes. nucleic acids research. sup:w194-200.

3. zhao c, coughlin jm, ju j, zhu d, wendt-pienkowski e, zhou x, wang z, shen b, deng z (2010). oxazolomycin biosynthesis in streptomyces albus ja3453 featuring an "acyltransferase-less" type i polyketide synthase that incorporates two distinct extender units. journal of biological chemistry. 25;285(26):20097-108.

4. chen w, huang t, he x, meng q, you d, bai l, li j, wu m, li r, xie z, zhou h, zhou x, tan h, deng z. (2009) characterization of the polyoxin biosynthetic gene cluster from streptomyces cacaoi and engineered production of polyoxin h. journal of biological chemistry.17;284(16):10627-38.

5. liu t, cane de, deng z. (2009) the enzymology of polyether biosynthesis. methods in enzymology, 459:187-214.

6. xu h, zhang y, yang j, mahmud t, bai l, deng z. (2009) alternative epimerization in c(7)n-aminocyclitol biosynthesis is catalyzed by vald, a large protein of the vicinal oxygen chelate superfamily. chemistry & biology, 16(5):567-76.

7. zhou y, li j, zhu j, chen s, bai l, zhou x, wu h, deng z. (2008) incomplete beta-ketone processing as a mechanism for polyene structural variation in the fr-008/candicidin complex. chemistry & biology,15(6):629-38.

8. liu t, lin x, zhou x, deng z, cane de. (2008) mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. chemistry & biology, 15(5):449-58.

9. zhao p, bai l, ma j, zeng y, li l, zhang y, lu c, dai h, wu z, li y, wu x, chen g, hao x, shen y, deng z, floss hg. (2008) amide n-glycosylation by asm25, an n-glycosyltransferase of ansamitocins. chemistry & biology. 15(8):863-74

10. l. wang, s. chen, t. xu, k. taghizadeh, j. s. wishnok, x. zhou, d. you, z. deng*, peter c. dedon* (2007), phosphorothioation of dna in bacteria by dnd gene clusters, nature chemical biology, 3(11):709-710. (featured by “news & views” written by fritz eckstein, nature chem. biol. 3(11): 689-690, and by acs “c&e news” written by carmen drahl).

11. x. he, h. ou, q. yu, x. zhou, j. wu, j. liang, w. zhang, k. rajakumar, and z. deng (2007). analysis of a genomic island housing genes for dna s-modification system in streptomyces lividans 66 and its counterparts in other distantly related bacteria, molecular microbiology, 65(4):1034-48.

12. h. ou, x. he, e. harrison, b. kulasekara, a. thani, a. kadioglu, s. lory, j. hinton, m. barer, z. deng (2007): mobilomefinder: web-based tools for in silico and experimental discovery of bacterial genomic islands, nucleic acids research. 5: w97-w104..

13. j. liang, z. wang, x. he, j. li, x. zhou, and z. deng (2007). dna modification by sulphur: analysis of the sequence recognition specificity surrounding the modification sites. nucleic acids research. 35(9):2944-54.

14. t liu, d you, c valenzano, y sun, j li, q yu, x zhou, d. cane, z deng (2006): identification of nane as the thioesterase for polyether chain release in nanchangmycin biosynthesis, chemistry & biology, 13(9):945-55.

15. l bai, l li, h xu, k minagawa, y yu, y zhang, x zhou, h g. floss, t mahmud, and z deng (2006): functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine a, chemistry & biology, 13, 387-397. (highlighted in nature biotechnology 24 (6): 665, 2006)。

16. t liu, d you, c valenzano, y sun, j li, q yu, x zhou, d. cane, z deng (2006): identification of nane as the thioesterase for polyether chain release in nanchangmycin biosynthesis, chemistry & biology, 13(9):945-55.

17. l bai, l li, h xu, k minagawa, y yu, y zhang, x zhou, h g. floss, t mahmud, and z deng (2006): functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine a, chemistry & biology, 13, 387-397. (highlighted in nature biotechnology 24 (6): 665, 2006)。

18. z. deng and l. bai (2006), antibiotic biosynthetic pathways and pathway engineering--a growing research field in china, natural product reports,23, 811 - 827.

19. x. zhou, x. he, j. liang., t. xu, a. li, t. kieser, j. d. helmann and z. deng (2005): a novel dna modification by sulphur, molecular microbiology, 57(5): 1428-20. d. zhu, x. he, x. zhou, and z. deng (2005): expression of the melc operon in several streptomyces strains is positively regulated by adpa, an arac family transcriptional regulator involved in morphological development in streptomyces coelicolor, journal of bacteriology, 187(9): 3180-3187.

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