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胡锦跃、 黄鹤、李红良、 张 旗、 叶晓茜、 尚政军、 郭继华、 张玉峰、
周海兵、 刘天罡、 王连荣、 瞿旭东、洪 葵
教研动态
刘天罡教授课题组真菌嵌合萜类合酶研究取得新进展
2021-07-23 11:13:06 来源:药学院 点击数:

新闻网讯(通讯员姚苑)近日,PNAS(《美国科学院院报》)在线发表了火狐体育药学院刘天罡教授课题组与美国田纳西大学陈峰教授课题组火狐体育真菌嵌合萜类合酶的合作研究成果。论文题目为“Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis”(《利用高效萜类前体供给的酿酒酵母底盘系统挖掘真菌嵌合萜类合酶》)。

火狐体育yaoxueyuanboshiyanjiushengchenrongweidiyizuozhe,liutiangang、yaoxueyuantepinfuyanjiuyuanbianguangkaihechenfengweigongtongtongxunzuozhe,火狐体育weidiyizuozhedanwei。

tieleihuahewushiguangfancunzaiyuziranjiezhong、shuliangzuipangdadeyileitianranchanwujiazu,zhijinyichaoguo10wanzhongjiegoubeifaxian,qizhongjiubaohanyouzhumingfenziqinghaosuhezishanchundeng。tieleihemeizaitieleihuahewushengwuhechengzhongfahuilefenzichenghuandengzhongyaogongneng,shitieleihuahewutangujiahechengdeguanjian。qizhong,ixingqianhetieleihemeishicunzaiyuzhenjuntineiyileixiyoudetieleihemei,youyiwuxijizhuanyimei(prenyltransferase,pt)jiegouyuheixingtieleihechengmei(terpene synthase,ts)jiegouyuzucheng(jianchengweiptts)。suizhejiyinzucexujishudefazhan,jibaigepttsfuchushuimian,ranerzhijinjinyoudayue20gepttsdegongnengbeiyanzheng。youxiandeshujushidewomennanyiduizheiyileixiyoutieleihemeideqiyuan、gongnengjinhuadengjinxingshenruqiequanmiandetansuo。

34个新PTTSs的系统发育分析以及产物结果

liutianganghechenfengketizucong476zhongjiyinzucexusizhuangzhenjunyijincbiheuniprotshujukuzhongshaixuanchule227gepttsjiyin。chenfengtongguoshengwuxinxixueshouduanduipttsjiyindeqiyuanhegongnengjinhuajinxingletansuo,faxianzheileimeiqiyuanyushuanghejunyajie,guangfanfenbuyuzinangjunmengegexizhong,erzaidanzijunmenzhongjinfenbuzaiyigezhongzhong。weilejiexizheileixiyoutieleihemeijiazudegongneng,liutiangangketizuliyongqikaifadegaoxiaotieleiqiantigongjideniangjiujiaomuweidipanbingjiehegaotongliangzidonghuapingtai,youxiaodishixianlepttsdiwudegaoxiaogongjibingqiedadazengjialepttswajuedetongliang,weigengshencengciditanjiupttsdegongnengtigongleqiangyoulidebaozhang。zuizhong,gaituanduichenggongdijiandingle34gexindepttsdegongneng,gaiyanjiuzhongjiandingdepttsdezongshuchaoguolemuqiansuoyouyizhidepttsdeyibei。lingwai,cong34gejiaomugongchengjunzhuzhongjiandingle24geertieheerbeibantiejiegou,bingjiezhujisuanhuaxuehehuaxuefanyingdefangshiquedinglelianggejiegouxinyingdeerbeibantiedejueduigouxing。

gaicelvebujinweitieleihuahewudewajuetigongleyigeqiangdahegaoxiaodefangfa,bingqiejiangtianranchanwufaxiancongyuanlaizaiziranjiexunzhaofazhanweicongwangshangwajuexinxibingzidonghuashixian,biaozhizhetieleitianranchanwuwajuejinruyigexindejieduan。zheiyeshigaiketizutichude“jiyudaixiegongchengpingtaidetieleihuahewuwajuexincelve”lianxuzaimetabolic engineering(《daixiegongcheng》)、current opinion in biotechnology(《shengwujishuxinguandian》)、angewandte chemie international edition(《deguoyingyonghuaxue》)、journal of american chemicalsociety(《meiguohuaxuexuebao》)、naturecommunications(《ziran·tongxun》)dengguojizhumingqikanfabiaotieleichanwuwajuexinfangfajichanwuhechengjizhiyilai,zaicizaigailingyuqudedezuixintupo。

gaiyanjiugongzuodedaohechengshengwuxueguojiazhongdianyanfajihua、guojiazirankexuejijin、火狐体育yixuekexuejinbujihuahezhongyanggaoxiaojibenkeyanjingfeidezizhu。

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